Polyurethanes ayaa si weyn loogu isticmaalaa codsiyada cilmiga noolaha sida maqaarka macmalka ah, gogosha cisbitaalka, tuubooyinka sifaynta, qaybaha wadnaha garaaca, tuubbadayaal, iyo dahaarka qalliinka.Is-waafajinta noolaha, qalabka farsamada, iyo qiimaha jaban ayaa ah qodobbada ugu waaweyn ee guusha polyurethane ee goobta caafimaadka.

Horumarinta implants inta badan waxay u baahan tahay maaddo sare oo ka kooban qaybaha biobased, sababtoo ah jidhku wuu diidaa iyaga wax yar.Xaaladda polyurethane, qaybta biocomponent waxay ku kala duwanaan kartaa 30 ilaa 70%, taas oo abuuraysa baaxad ballaadhan oo loogu talagalay codsiyada meelahaas (2).Polyurethane-ka bayoolajiga ah ayaa kordhinaya saamigooda suuqa waxaana la filayaa inay gaaraan $42 milyan marka la gaaro 2022, taas oo ah boqolkiiba wax yar oo ka mid ah suuqa guud ee polyurethane (in ka yar 0.1%).Si kastaba ha ahaatee, waa aag rajo leh, waxaana socda cilmi baaris xooggan oo ku saabsan isticmaalka walxo badan oo noole ku salaysan polyurethane.Hagaajinta ayaa loo baahan yahay sifaha polyurethane-ku-salaysan si loo waafajiyo shuruudaha jira, si kor loogu qaado maalgashiga.

Polyurethane crystalline biobased waxaa lagu sameeyay falcelinta PCL, HMDI, iyo biyaha ciyaaray doorka silsiladaha fidiyaha33).Tijaabooyin hoos u dhac ayaa la sameeyay si loo daraaseeyo xasilloonida biopolyurethane ee dareeraha jirka ee la isku daray, sida xalalka milixda ee fosfat-buffered.Isbedelka

kuleyl, farsamo, iyo sifooyin jireed ayaa la falanqeeyay oo la barbardhigay wax u dhigma

polyurethane waxaa lagu helay iyadoo la isticmaalayo ethylene glycol sidii silsilad fidiyaha halkii biyo.Natiijooyinku waxay muujiyeen in polyurethane-ka la helay iyadoo la isticmaalayo biyaha sidii silsilad fidiye ah ay soo bandhigtay sifooyin wanaagsan waqti ka dib marka la barbar dhigo kiimikaad u dhigma.Tani ma aha oo kaliya si weyn hoos u dhac

Qiimaha habka, laakiin sidoo kale waxay bixisaa dariiq sahlan oo lagu helo qalab caafimaad oo qiimo leh oo ku habboon endorstheses wadajir ah (33).Tan waxa raacay hab kale oo ku salaysan fikraddan, kaas oo soo saaray urea biopolyurethane iyada oo la adeegsanayo polyol saliid ku salaysan kufsiga, PCL, HMDI, iyo biyaha sidii silsilad fidsan6).Si loo kordhiyo aagga dusha sare, koloriin sodium ayaa loo isticmaalay si loo hagaajiyo porosity ee polymers-ka la diyaariyey.Polymerized-ka la sameeyay ayaa loo isticmaalay sidii qolof ah sababtoo ah qaab-dhismeedkiisa daloolka ah si uu u kiciyo koritaanka unugyada unugyada lafaha.Iyadoo natiijooyin isku mid ah la barbar dhigo

Tusaalaha hore, poliurethane ee lagu soo bandhigay dareeraha jirka ee la isku daray ayaa soo bandhigay xasilooni sare, oo bixisa ikhtiyaar macquul ah oo loogu talagalay codsiyada qashinka.Polyurethane ionomers waa nooc kale oo xiiso leh oo polymers ah oo loo isticmaalo codsiyada biomedical, taas oo ka dhalata is-waafajintooda iyo isdhexgalka saxda ah ee deegaanka jirka.Polyurethane ionomers waxaa loo isticmaali karaa sida qaybaha tuubada ee wadnaha wadnaha iyo hemodialysis (34, 35).

Horumarinta habka bixinta dawooyinka waxtarka leh waa aag cilmi-baaris oo muhiim ah oo hadda diiradda saareysa sidii loo heli lahaa habab lagu yareeyo kansarka.Nanoparticle amphiphilic ah oo ah polyurethane oo ku salaysan L-lysine ayaa loo diyaariyey codsiyada gudbinta daroogada (36).Nanocarrier kan

ayaa si wax ku ool ah loogu shubay doxorubicin, taas oo ah daawaynta daawada waxtarka leh ee unugyada kansarka (Jaantuska 16).Qaybaha hydrophobic ee polyurethane ayaa la falgalay daroogada, iyo qaybaha hydrophilic waxay la falgalaan unugyada.Nidaamkani wuxuu abuuray qaab dhismeed xudun u ah iyada oo loo marayo is-ururin

habka iyo waxa uu awooday in uu si hufan u gaarsiiyo daawooyinka iyada oo loo marayo laba waddo.Marka hore, jawaabta kulaylka ee nanoparticle waxay u dhaqmeen sidii kicinta siideynta daawada heerkulka unugyada kansarka (~ 41-43 ° C), taas oo ah jawaab celin ka baxsan unugyada.Marka labaad, qaybaha aliphatic ee polyurethane ayaa soo gaaray

biodegradation enzymatic by ficilka lysosomes, u oggolaanaya doxorubicin in lagu sii daayo gudaha unugyada kansarka;Tani waa jawaab celinta unugyada.In ka badan 90% unugyada kansarka naasaha ayaa la dilay, halka cytotoxicity hooseeya loo ilaaliyo unugyada caafimaadka qaba.

Jaantuska 16. Nidaamka guud ee habka gudbinta daroogada ee ku salaysan nanoparticle polyurethane amphiphilic

si loo beegsado unugyada kansarka. Dib loo soo saaray iyadoo ogolaansho laga haysto tixraac(36).Xuquuqda daabacaadda 2019 Kiimikada Maraykanka

Bulshada.

Baaq: Maqaalka waxaa laga soo xigtayHordhac Kiimikada PolyurethaneFelipe M. de Souza, 1 Pawan K. Kahol, 2 iyo Ram K.Gupta *,1.Kaliya isgaarsiinta iyo barashada, ha sameynin ujeeddooyin kale oo ganacsi, ma matalo aragtida iyo fikradaha shirkadda, haddii aad u baahan tahay inaad dib u daabacdo, fadlan la xiriir qoraaga asalka ah, haddii ay jirto xad-gudub, fadlan nala soo xiriir isla markaaba si aad u sameyso tirtirista.